The Association of Fatty Acids with Prostate Cancer Risk.
The Association of Fatty Acids with Prostate Cancer Risk.
Year: 2001
Authors: Newcomer, L.M., King, I.B., Wicklund, K.G. Stanford, J.L.
Publication Name: The Prostate
Publication Details: Volume 47, Pages 262-68.
Abstract:
BACKGROUND. Animal studies indicate that omega-6 fatty acids promote and omega-3 fatty acids inhibit tumor development. This pilot study was designed to evaluate whether these fatty acids are associated with human prostate cancer.
METHODS. Levels of erythrocyte membrane omega-3 and omega-6 fatty acids were determined for 67 incident prostate cancer cases and 156 population-based controls.
RESULTS. Prostate cancer risk was increased in the highest compared to the lowest quartile of a-linolenic acid (OR=2.6, 95% CI=1.1-5.8, trend P=0.01). Positive associations were also observed with higher levels of linoleic acid (OR=2.1, 95% CI=0.9 – 4.8) and total omega-6 fatty acids (OR=2.3, 95% CI=1.0-5.4).
CONCLUSIONS. Results are consistent with other studies showing that linoleic and total omega-6 fatty acids increase risk of prostate cancer. Contrary to animal studies, a-linolenic acid was also positively associated with risk. Further research will be required to clarify the role of these fatty acids in human prostate cancer. Author's Abstract.
METHODS. Levels of erythrocyte membrane omega-3 and omega-6 fatty acids were determined for 67 incident prostate cancer cases and 156 population-based controls.
RESULTS. Prostate cancer risk was increased in the highest compared to the lowest quartile of a-linolenic acid (OR=2.6, 95% CI=1.1-5.8, trend P=0.01). Positive associations were also observed with higher levels of linoleic acid (OR=2.1, 95% CI=0.9 – 4.8) and total omega-6 fatty acids (OR=2.3, 95% CI=1.0-5.4).
CONCLUSIONS. Results are consistent with other studies showing that linoleic and total omega-6 fatty acids increase risk of prostate cancer. Contrary to animal studies, a-linolenic acid was also positively associated with risk. Further research will be required to clarify the role of these fatty acids in human prostate cancer. Author's Abstract.
