Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus
Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype induced mouse model of systemic lupus erythematosus
Year: 1998
Authors: Reifen, R., Blank, M., Afek, A., Kopilowiz, Y., Sklan, D., Gershwin, M.E., German, B. et al
Publication Name: Lupus
Publication Details: Volume 7; Pages 192 – 197
Abstract:
Objective: To examine the effect of diets with different polyunsaturated fatty acid contents, including linseed oil which contains 70% omega-3 fatty acids, on autoantibody production in idiotype induced mouse model of systemic lupus erythematosus (SLE).
Methods: Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out.
Results: SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil.
Conclusion: Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well. Author's Abstract.
Methods: Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out.
Results: SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil.
Conclusion: Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well. Author's Abstract.
