Brain DHA restoration in young deficient rat is better with pure or blended dairyfat diets compared to similar ALA content vegetable blends
Brain DHA restoration in young deficient rat is better with pure or blended dairyfat diets compared to similar ALA content vegetable blends
Year: 2014
Authors:
Publication Name: ISSFAL International Congress, Stockholm, Sweden June 28 – July 1
Publication Details: ID# Monday N5.03
Abstract:
Background and aims: Achieving an appropriate DocosaHexaenoic Acid (DHA) status in the neonatal brain is an important goal of neonatal nutrition. In an attempt to validate the potential replacement of vegetable fat with dairy fat in infant formulas, we used the brain DHA level of rats as a nutritional model to compare the effects of blends based on dairy fat instead of palm oil. Methods: Six groups of 10 males rats, born from dams fed low 0.4 percent ALA diet over
Gestation lactation, received, for 6 weeks after weaning, diets providing either similar 1.5 percent ALA (from rapeseed) recommended for infant formulas, blended with (i) dairy fat, (ii) palm oil, or (iii) increased to 2.3 percent ALA dairy fat and were compared to diets containing pure 0.4 percent ALA palm, pure 0.8 percent ALA dairy fat and pure 8 percent ALA rapeseed Results: Restoration of brain DHA levels was superior with the 1.5 percent ALA dairy fat compared to 1.5 percent ALA palm blend (plus 80 percent vs plus 60 percent p less 0.001). Increasing to 2.3 percent ALA dairy fat blend induced a further increase ( plus90 percent) and was as efficient as pure 0.8 percent ALA dairy fat or 8 percent ALA rapeseed diets, while 0.4 percent ALA palm diet was only 30 percent. Conclusions: 1. Brain DHA restoration of young deficient rats is more efficient with 1.5 percent ALA dairy fat blend diet compared to similar 1.5 percent ALA vegetable blend (specificity/complexity of dairy fat matrix could be involved). 2. Brain DHA restoration is even more efficient with a 2.3 percent ALA dairy fat blend diet compared to the previous ones (higher level of ALA and a better n6 to n3ratio (5 vs10) could be involved). 3. Brain DHA restoration with a 2.3 percent ALA dairy fat blend diet is comparable to pure 8 percent ALA rapeseed diet. 4. Pure 0.8 percent ALA dairy fat is 3 times better than pure 0.4 percent ALA palm despite similar ALA levels (better n6 to n3ratio 2.3 vs 21). 5. Pure 0.8 percent ALA dairy fat is as efficient as pure 8 percent ALA rapeseed despite 10 times less ALA (similar n6 to n3 ratio 2.3 associated to a lower Delta 6 desaturase competition within the n3 family between ALA and DHA of dairy fat matrix). Use of dairy fat for infant formulas should be reconsidered. (Authors abstract)
Gestation lactation, received, for 6 weeks after weaning, diets providing either similar 1.5 percent ALA (from rapeseed) recommended for infant formulas, blended with (i) dairy fat, (ii) palm oil, or (iii) increased to 2.3 percent ALA dairy fat and were compared to diets containing pure 0.4 percent ALA palm, pure 0.8 percent ALA dairy fat and pure 8 percent ALA rapeseed Results: Restoration of brain DHA levels was superior with the 1.5 percent ALA dairy fat compared to 1.5 percent ALA palm blend (plus 80 percent vs plus 60 percent p less 0.001). Increasing to 2.3 percent ALA dairy fat blend induced a further increase ( plus90 percent) and was as efficient as pure 0.8 percent ALA dairy fat or 8 percent ALA rapeseed diets, while 0.4 percent ALA palm diet was only 30 percent. Conclusions: 1. Brain DHA restoration of young deficient rats is more efficient with 1.5 percent ALA dairy fat blend diet compared to similar 1.5 percent ALA vegetable blend (specificity/complexity of dairy fat matrix could be involved). 2. Brain DHA restoration is even more efficient with a 2.3 percent ALA dairy fat blend diet compared to the previous ones (higher level of ALA and a better n6 to n3ratio (5 vs10) could be involved). 3. Brain DHA restoration with a 2.3 percent ALA dairy fat blend diet is comparable to pure 8 percent ALA rapeseed diet. 4. Pure 0.8 percent ALA dairy fat is 3 times better than pure 0.4 percent ALA palm despite similar ALA levels (better n6 to n3ratio 2.3 vs 21). 5. Pure 0.8 percent ALA dairy fat is as efficient as pure 8 percent ALA rapeseed despite 10 times less ALA (similar n6 to n3 ratio 2.3 associated to a lower Delta 6 desaturase competition within the n3 family between ALA and DHA of dairy fat matrix). Use of dairy fat for infant formulas should be reconsidered. (Authors abstract)
