Association Between a Low Adipose Tissue Content of Polyunsaturated Fatty Acids and Both Glucose Intolerance and Hypertriglyceridemia in Apparently Healthy Men.
Association Between a Low Adipose Tissue Content of Polyunsaturated Fatty Acids and Both Glucose Intolerance and Hypertriglyceridemia in Apparently Healthy Men.
Year: 1975
Authors: L A Carlson, G Walldius.
Publication Name: Acta Med. Scand.
Publication Details: Volume 197; Page 295.
Abstract:
Abnormalities in adipose tissue (AT), in particular increased AT mass with large fat cells, have been associated with glucose tolerance (GT) and hypertriglyceridemia (HTG). The basis for this association is not known. The objective of this study was to examine whether the FA composition of AT may be related to GI and HTG. The FA composition AT lipids was determined in 43 apparently healthy men with different levels of plasma TGs and different degrees of GT. Compared to men with normal plasma TG levels, men with HTG showed similar levels of LA but lower levels of ALA and AA. Decreasing concentrations of AT ALA were positively correlated to declining GT and negatively to plasma TG. The authors noted that previous research has indicated that low levels of ALA in AT is common both in HTG and GI and might partly explain reported associations between these two metabolic disorders. Since the content of LA was normal, the investigators speculated that the low levels of ALA and AA may have been caused by both metabolic and dietary factors. The authors speculate that low levels of ALA and AA may play a role in the pathogenesis of GI and HTG.
