Effect of a Semi solid Formulation of Linum usitatissimum L. (Linseed) Oil on the Repair of Skin Wounds
Effect of a Semi solid Formulation of Linum usitatissimum L. (Linseed) Oil on the Repair of Skin Wounds
Year: 2011
Authors: de Souza Franco, E. Ferreira de Aquino, C.M. Lys de Medeiros, P. Evencio, L.B. da Silva Goes, A.J. de Souza Maia , M.B.
Publication Name: Evidence-Based Complementary and Alternative Medicine
Publication Details: doi:10.1155/2012/270752
Abstract:
The purpose of this study was to investigate the effects of a semisolid formulation of linseed oil, SSFLO (1%, 5%, or 10%) or in natural linseed oil on skin wounds of rats. We used wound models, incisional and excisional, to evaluate, respectively, the contraction/reepithelialization of the wound and resistance to mechanical traction. The groups (n= 6) treated with SSFLO (1% or 5%) began the process of reepithelialization, to a significant extent (P<.05), on the sixth day, when compared to the petroleum jelly control group. On 14th day for the groups treated with SSFLO (1% or 5%), 100% reepithelialization was found, while in the petroleum jelly control group, this was only 33.33%. Our study showed that topical administration of SSFLO (1% or 5%) in excisional wounds allowed reepithelialization in 100% of treated animals. Therefore, a therapeutic potential of linseed oil, when used at low concentrations in the solid pharmaceutical formulations, is suggested for the process of dermal repair. (Authir's abstract)
In rats treated topically with purified linolenic, linoleic and oleic acid, wound healing was improved by MUFA oleic or PUFA linoleic. Linoleic acid (ω-6) is the direct precursor of arachidonic acid, which is part of the membrane phospholipids and which prevents trans epidermal water loss, provides elasticity, skin integrity and fluidity. the objective of the present study was to explore two cases of healing activity using a semi solid formulation of linseed oil in experimental models of skin wounds. Standardized surgical wounds were prepared, which were submitted to the repair process in the first intention (incisional model) and second intention (excisional model) for ten or fourteen days of treatment, respectively, with SSFLO (1%, 5%, or 10%) or linseed oil. A significant increase in the area of the wounds treated with linseed oil on the fourth and fifth days were observed, when compared to the petroleum jelly control. Linseed oil is rapidly absorbed, allowing the wound bed to become more exposed to the environment leading to the formation of scabs. The significantly earlier appearance of granulation tissue around of the wound in animals treated with the 1% or 5% SSFLO, when compared to the ESO control group, may be attributed to the semisolid formulation, as an emollient and occlusive vehicle (petroleum jelly), allowed the wound to remain hydrated, due to the occlusion process that decreased the net loss to the environment. Histological analysis performed at the end of the experiment (day 14) showed that the groups treated with SSFLO (1% or 5%) showed significant reepithelialization compared to negative control (petroleum jelly), but the same was not observed in groups treated with 10% SSFLO or linseed oil. A significant amount of inflammatory cells in the group treated with 10% SSFLO were reported. Topical administration of SSFLO (1% or 5%) in experimental excisional wounds promotes reepithelialization in 100% of the animals treated, therefore indicating the potential for therapeutic action of linseed oil when used at low concentrations in dermatological formulas . (Editor's comments)
In rats treated topically with purified linolenic, linoleic and oleic acid, wound healing was improved by MUFA oleic or PUFA linoleic. Linoleic acid (ω-6) is the direct precursor of arachidonic acid, which is part of the membrane phospholipids and which prevents trans epidermal water loss, provides elasticity, skin integrity and fluidity. the objective of the present study was to explore two cases of healing activity using a semi solid formulation of linseed oil in experimental models of skin wounds. Standardized surgical wounds were prepared, which were submitted to the repair process in the first intention (incisional model) and second intention (excisional model) for ten or fourteen days of treatment, respectively, with SSFLO (1%, 5%, or 10%) or linseed oil. A significant increase in the area of the wounds treated with linseed oil on the fourth and fifth days were observed, when compared to the petroleum jelly control. Linseed oil is rapidly absorbed, allowing the wound bed to become more exposed to the environment leading to the formation of scabs. The significantly earlier appearance of granulation tissue around of the wound in animals treated with the 1% or 5% SSFLO, when compared to the ESO control group, may be attributed to the semisolid formulation, as an emollient and occlusive vehicle (petroleum jelly), allowed the wound to remain hydrated, due to the occlusion process that decreased the net loss to the environment. Histological analysis performed at the end of the experiment (day 14) showed that the groups treated with SSFLO (1% or 5%) showed significant reepithelialization compared to negative control (petroleum jelly), but the same was not observed in groups treated with 10% SSFLO or linseed oil. A significant amount of inflammatory cells in the group treated with 10% SSFLO were reported. Topical administration of SSFLO (1% or 5%) in experimental excisional wounds promotes reepithelialization in 100% of the animals treated, therefore indicating the potential for therapeutic action of linseed oil when used at low concentrations in dermatological formulas . (Editor's comments)
