Effect of fish oil on lipoproteins, lecithin:cholesterol acyltransferase, and lipid transfer protein activity in humans
Effect of fish oil on lipoproteins, lecithin:cholesterol acyltransferase, and lipid transfer protein activity in humans
Year: 1990
Authors: Abbey, M., Clifton, P., Kestin, M., Belling, B., Nestel, P.
Publication Name: Arterioscler. Thromb. Vasc. Biol.
Publication Details: Volume 10, Pages 85-94.
Abstract:
A group of 33 mildly hypercholesterolemlc men were stratified Into three groups on diets closely matched except for the polyunsaturated fatty acid supplement The first group received 14 g/day of linolenic acid (safflower oil); the second group, 9 g of a-linolenic add (linseed oil); and the third group, 3.8 g of n-3 fatty acids (fish oil). Only fish oil lowered plasma triglycerides (by 24% at 6 weeks, p<0.05 compared to
safflower oil). Very low density lipoprotein (VLDL) apoprotein (apo) B, triglyceride, and cholesterol all fell significantly with the fish-oil diet (p<0.01). Low density lipoprotein (LDL) cholesterol fell by 0.18 and 0.10 mmol/l, respectively, with the safflower-oil and linseed-oil diets, but rose by 0.24 mmol/l with the fish-oil diet (p<0.05). There was a strong correlation between the changes In VLDL triglyceride and LDL cholesterol with the fish-oil diet (r=-O.84,p<0.002). High density lipoprotein (HDL) cholesterol fell slightly In all three groups (p<0.02 with the linseed-oil diet only). However, the apo A-l/A-ll ratio rose by 5% (p<0.05), and the HDL2/HDL3, protein ratio Increased by 28% with the fish-oil diet (p<0.005). Fish oil reduced the capacity for transfer of cholesteryl ester between LDL and HDL by 23% (p< 0.02 compared to baseline), reduced plasma lecithin:cholesterol acyltransferase activity by 21% (p<0.05), and reduced maximal stimulated thromboxane production by 9% (p<0.05). Thus fish oil produced three potentially beneficial changes: significant decreases in VLDL concentration and in thromboxane production and an increase In the HDL2/HDL3, ratio. The Increase In the average HDL particle size probably reflected reduced cholesteryl ester acceptor capacity within the smaller pool of VLDL, as well as the decline in lipld transfer activity in plasma involving transfer protein Itself, LDL, and HDL. Author's Abstract.
safflower oil). Very low density lipoprotein (VLDL) apoprotein (apo) B, triglyceride, and cholesterol all fell significantly with the fish-oil diet (p<0.01). Low density lipoprotein (LDL) cholesterol fell by 0.18 and 0.10 mmol/l, respectively, with the safflower-oil and linseed-oil diets, but rose by 0.24 mmol/l with the fish-oil diet (p<0.05). There was a strong correlation between the changes In VLDL triglyceride and LDL cholesterol with the fish-oil diet (r=-O.84,p<0.002). High density lipoprotein (HDL) cholesterol fell slightly In all three groups (p<0.02 with the linseed-oil diet only). However, the apo A-l/A-ll ratio rose by 5% (p<0.05), and the HDL2/HDL3, protein ratio Increased by 28% with the fish-oil diet (p<0.005). Fish oil reduced the capacity for transfer of cholesteryl ester between LDL and HDL by 23% (p< 0.02 compared to baseline), reduced plasma lecithin:cholesterol acyltransferase activity by 21% (p<0.05), and reduced maximal stimulated thromboxane production by 9% (p<0.05). Thus fish oil produced three potentially beneficial changes: significant decreases in VLDL concentration and in thromboxane production and an increase In the HDL2/HDL3, ratio. The Increase In the average HDL particle size probably reflected reduced cholesteryl ester acceptor capacity within the smaller pool of VLDL, as well as the decline in lipld transfer activity in plasma involving transfer protein Itself, LDL, and HDL. Author's Abstract.
