Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis.
Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis.
Year: 2004
Authors: Bemelmans, W.J.E., Lefrandt,J.D., Feskens, E.M.J., van Haelst, P.L., Broer, J., Meyboom-de Jong, B., May, J.F., et al.
Publication Name: Eur. J. Clin. Nutr.
Publication Details: Volume 58, Pages 1083–1089.
Abstract:
Objective: To investigate the effects of increased alpha-linolenic acid (ALA)-intake on intima–media thickness (IMT), oxidized low-density lipoprotein (LDL) antibodies, soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP), and interleukins 6 and 10.
Design: Randomized double-blind placebo-controlled trial.
Subjects: Moderately hypercholesterolaemic men and women (55±10y) with two other cardiovascular risk factors (n=103).
Intervention: Participants were assigned to a margarine enriched with ALA (fatty acid composition 46% LA, 15% ALA) or linoleic acid (LA) (58% LA, 0.3% ALA) for 2 y.
Results: Dietary ALA intake was 2.3 en% among ALA users, and 0.4 en% among LA users. The 2-y progression rate of the mean carotid IMT (ALA and LA: +0.05mm) and femoral IMT (ALA:+0.05 mm; LA:+0.04mm) was similar, when adjusted for confounding variables. After 1 and 2 y, ALA users had a lower CRP level than LA users (net differences -0.53 and – 0.56 mg/l, respectively, P<0.05). No significant effects were observed in oxidized LDL antibodies, and levels of sICAM-1, interleukins 6 and 10.
Conclusions: A six-fold increased ALA intake lowers CRP, when compared to a control diet high in LA. The present study found no effects on markers for atherosclerosis.
Sponsorship: The Dutch ‘Praeventiefonds’. Author's Abstract.
Design: Randomized double-blind placebo-controlled trial.
Subjects: Moderately hypercholesterolaemic men and women (55±10y) with two other cardiovascular risk factors (n=103).
Intervention: Participants were assigned to a margarine enriched with ALA (fatty acid composition 46% LA, 15% ALA) or linoleic acid (LA) (58% LA, 0.3% ALA) for 2 y.
Results: Dietary ALA intake was 2.3 en% among ALA users, and 0.4 en% among LA users. The 2-y progression rate of the mean carotid IMT (ALA and LA: +0.05mm) and femoral IMT (ALA:+0.05 mm; LA:+0.04mm) was similar, when adjusted for confounding variables. After 1 and 2 y, ALA users had a lower CRP level than LA users (net differences -0.53 and – 0.56 mg/l, respectively, P<0.05). No significant effects were observed in oxidized LDL antibodies, and levels of sICAM-1, interleukins 6 and 10.
Conclusions: A six-fold increased ALA intake lowers CRP, when compared to a control diet high in LA. The present study found no effects on markers for atherosclerosis.
Sponsorship: The Dutch ‘Praeventiefonds’. Author's Abstract.
