Lipid Peroxides and Essential Fatty Acids in Patients with Coronary Heart Disease.
Lipid Peroxides and Essential Fatty Acids in Patients with Coronary Heart Disease.
Year: 1994
Authors: K Vijay Kumar, U N Das.
Publication Name: J. Nutr. Med.
Publication Details: Volume 4; Number 1; Page 33.
Abstract:
CHD has been reported to be more prevalent in Indian populations than in individuals consuming a Western style diet. Free radical damage to LDL-C through oxidative processes may initiate the process of atherosclerosis and was the subject of interest in this study. In this study, levels of plasma EFA and a lipid peroxide metabolite, malondialdehyde (MDA) were measured in humans with CHD. Blood was sampled from 20 men of 35 to 55 years old with CHD living in India, and from 20 normal controls. The results indicated that in men with CHD, MDA were high. In contrast, GLA and metabolites of ALA, EPA and DHA were significantly decreased in the plasma PL fraction. EPA and DHA have been shown to be protective against CHD. The authors concluded that their results suggest that increased formation of lipid peroxides such as MDA, as a result of enhanced free radical generation, and low plasma EPA and DHA are closely associated with CHD in Indians. A dietary supplementation study using the n-3 fatty acids, ALA, EPA and DHA is planned as a follow-up to this research.
