Reducing Atherogenic Risk in hyperlipidemic humans with flaxseed supplementation: A preliminary report.
Reducing Atherogenic Risk in hyperlipidemic humans with flaxseed supplementation: A preliminary report.
Year: 1993
Authors: M L Bierenbaum, R Reichstein, T R Watkins.
Publication Name: Amer. J. Coll. Nutr.
Publication Details: Volume 12; Number 5; Page 501.
Abstract:
High intakes of vitamin E have been shown to reduce the risk of atherogenesis in hyperlipidemic humans through decreases in lipid peroxidation and platelet aggregation. However, several studies have found no effects on serum lipid levels. The objective of this study was to determine the effects on serum lipids and lipid peroxidation of a combination of flaxseed supplementation plus vitamin E. Fifteen individuals with high blood cholesterol levels who had previously consumed 800 IU of vitamin E for a 3 month period were included in this trial. flaxseed products were added to the self-selected vitamin E enriched diets of the subjects for 3 months. The flaxseed supplements included 15 g of ground flaxseed (3.4 g ALA and 5.5 g of fiber) plus 3 slices of 10% flaxseed containing bread (1.2 g ALA and 10 g of fiber). There was a highly significant reduction in TC (18 mg/dL) and LDL-C (19 mg/dL reported following the flaxseed diet. HDL-C levels remained stable and TG decreased slightly. Lipid oxidation products increased slightly during the flaxseed period and then decreased significantly during a 1-month washout period. Thrombin-stimulated platelet aggregation decreased following the flaxseed diet. The results suggest that a combination of vitamin E and flaxseed can positively influence several atherogenic risk factors serum lipid levels, platelet aggregation and lipid peroxidation in individuals with hyperlipidemia.
